解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Post-stroke cognitive impairment (PSCI) is a series of syndromes that meet the diagnostic criteria for cognitive impairment that appear after a stroke. The treatment of PSCI with oral drugs alone is not ideal and has obvious side effects. Therefore, complementary and alternative treatments are needed for pat...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04656-w
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Osteoarthritis (OA) is a health condition sensitive to patient's preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs, and preferences into the ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04661-z
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND/AIMS:Prediabetes and diabetes disproportionately impact Latino youth, yet few diabetes prevention programs have prioritized inclusion of this underrepresented population. This report describes the recruitment process, yields, associated costs, and phenotypic characteristics of Latino youth with obesity and p...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04658-8
更新日期:2020-08-14 00:00:00
abstract:BACKGROUND:A core outcome set (COS) represents the agreed minimum set of domains and measurement instruments that should be measured and reported in any clinical trial for a given condition. In BMS randomized controlled trials (RCTs), the outcomes identified in the existing literature regarding the efficacy of therapeu...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04640-4
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a rapid-onset sensorineural hearing impairment with unclear etiology and unsatisfying treatment effects. Vestibular dysfunction has been considered as a poor indicator in the clinical manifestations and prognosis of ISSNHL, which occurred in approximat...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04579-6
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:The ability to retrieve specific memories is a cognitive and emotional protective factor. Among the most effective techniques to generate autobiographical memories is the use of audio-visual stimuli, particularly images. Developing and improving techniques that facilitate the generation of such memories coul...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04596-5
更新日期:2020-07-20 00:00:00
abstract:OBJECTIVES:To determine if lopinavir/ritonavir +/- hydroxychloroquine will reduce the proportion of participants who survive without requiring ventilatory support, 15 days after enrolment, in adult participants with non-critically ill SARS-CoV-2 infection. TRIAL DESIGN:ASCOT is an investigator-initiated, multi-centre,...
journal_title:Trials
pub_type: 信件,多中心研究
doi:10.1186/s13063-020-04576-9
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are sma...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04560-3
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04536-3
更新日期:2020-07-08 00:00:00
abstract:BACKGROUND:Chronic musculoskeletal pain (MSP) affects more than 40% of adults aged 50 years and older and is the leading cause of disability in the USA. Older adults with chronic MSP are at risk for analgesic-related side effects, long-term opioid use, and functional decline. Recognizing the burden of chronic MSP, redu...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04552-3
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Adolescent depression is a common mental health problem and there is an urgent need for effective and accessible treatments. Internet-based interventions solve many obstacles for seeking and receiving treatment, thus increasing access to effective treatments. Internet-based cognitive behavioural therapy (ICB...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04491-z
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Rural areas of India exhibit high neonatal mortality, and low literacy and numeracy. We assess the effect of a complex package of health interventions on neonatal survival and the effect of out-of-school-hours teaching on children's literacy and numeracy in rural Madhya Pradesh. METHODS/DESIGN:This is a clu...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04339-6
更新日期:2020-06-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Trials
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13063-020-04504-x
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:Temporomandibular disorder (TMD) is a condition encompassing clinical symptoms of the temporomandibular joint, masseter muscle, and surrounding structures. Hominis placental pharmacopuncture (HPP), consisting of human placental extract, has been reported as effective for treating chronic musculoskeletal diso...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04442-8
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Perineal pain due to episiotomy is commonly reported and can be severe enough to disturb the mother-infant dyad during the postpartum period. Its incidence at day 7 postpartum varies from 63% to 74%. Recent studies have investigated the analgesic efficacy of perineal infiltration of ropivacaine after episiot...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04423-x
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Less invasive surfactant administration (LISA) is a way of giving surfactant without endotracheal intubation and has shown to be promising in reducing the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. However, the mechanism underlying its beneficial effect and variations in the technique ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04390-3
更新日期:2020-06-11 00:00:00
abstract:OBJECTIVES:To evaluate the safety of therapeutic plasma exchange (TPE) in adult patients with serious/life-threatening COVID-19 requiring intensive care unit (ICU) admission, and associated 28-day mortality. Serious and life threatening COVID-19 are defined as per published literature (please, refer to the full protoco...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04454-4
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in a randomised prevention trial using a two-by-two factorial randomised s...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04373-4
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Despite efforts to improve the accuracy and transparency of the design, conduct, and reporting of randomised controlled trials (RCTs), deficiencies remain. Such deficiencies contribute to significant, avoidable waste of health research investment and impede reproducibility. This study aimed to synthesise and...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04396-x
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04445-5
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Recruiting and retaining participants in randomised controlled trials (RCTs) is challenging. Digital tools, such as social media, data mining, email or text-messaging, could improve recruitment or retention, but an overview of this research area is lacking. We aimed to systematically map the characteristics ...
journal_title:Trials
pub_type: 杂志文章,评审
doi:10.1186/s13063-020-04358-3
更新日期:2020-06-05 00:00:00
abstract:OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04455-3
更新日期:2020-06-05 00:00:00
abstract:OBJECTIVES:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about COVID-19 hygiene practices-such as social ...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04449-1
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Dentin hypersensitivity (DH) is a condition characterized by short and sharp episodes of pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort in patients and reduce their quality of life. Recently, the novel zinc-containing des...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04426-8
更新日期:2020-06-03 00:00:00
abstract:BACKGROUND:Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is r...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04366-3
更新日期:2020-06-02 00:00:00
abstract:BACKGROUND:Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare magnesium oxide with naldemedine and determine which is more effective in preventing OIC. METHODS:This proof-of-concept, prospective, randomized controlled...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04385-0
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04331-0
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this inter...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04410-2
更新日期:2020-05-29 00:00:00
abstract:BACKGROUND:Suffering linked to previous interpersonal trauma is common among patients in mental health care. Diagnostic labels may vary, but the clinical picture is often characterized by long-lasting and complex psychological and somatic symptoms, subjective distress and reduced quality of health and life. A substanti...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04297-z
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:An individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm (CARTA)) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to in...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-020-04332-z
更新日期:2020-05-12 00:00:00
abstract:BACKGROUND:Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill this knowledge gap, this protocol proposes an appropriately powered, prospective, evaluator-blinded, ...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-020-04271-9
更新日期:2020-05-11 00:00:00
abstract:BACKGROUND:Exploration and modelling of heterogeneous treatment effects as a function of baseline covariates is an important aspect of precision medicine in randomised controlled trials (RCTs). Randomisation generally guarantees the internal validity of an RCT, but heterogeneity in treatment effect can reduce external ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04306-1
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:This randomized controlled clinical trial aims to evaluate the efficacy and safety of opposing needling in patients undergoing unilateral total knee arthroplasty (TKA). Opposing needling is one of the special needling methods used in acupuncture and moxibustion therapy. It involves needling acupoints on the ...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-020-04251-z
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space-occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these procedures, patients often experience severe postoperative pain at the surgical site. Intense immediate postoperative pain after many ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04308-z
更新日期:2020-05-05 00:00:00
abstract:BACKGROUND:Depression has serious personal, family and economic consequences. It is estimated that it will cost £12.15 billion to the economy each year in England by 2026. Improving access to psychological therapies (IAPT) is the National Health Service talking therapies service in England for adults experiencing anxie...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04322-1
更新日期:2020-05-04 00:00:00
abstract:BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04286-2
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4230-6
更新日期:2020-04-23 00:00:00
abstract:BACKGROUND:A high intake of salt is a major risk factor for cardiovascular diseases. Despite decades of effort to reduce salt consumption, the salt intake in China is still considerably above the recommended level. Thus, this study aims to design and implement an intelligent household added salt monitoring system (SALT...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04295-1
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:Tobacco smoking remains the leading preventable cause of death in the US. A hospital admission provides smokers with a unique opportunity to stop smoking because it requires temporary tobacco abstinence while illness may enhance motivation to quit. Hospital interventions must continue post-discharge to incre...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04257-7
更新日期:2020-04-16 00:00:00
abstract:BACKGROUND:The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretation of the hazard ratio...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4153-2
更新日期:2020-04-06 00:00:00